Acquired idiopathic generalized anhidrosis

Abstract

Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder characterized by the inability to sweat in the absence of identifiable dermatological, neurological, or metabolic causes. We present the case of a 23-year-old woman whose symptoms began at the age of 8 years, with the progressive development of generalized anhidrosis associated with heat intolerance, pruritus, and erythematous cutaneous lesions exacerbated by elevated temperatures. Physical examination revealed erythematous to violaceous macules, papules, and plaques involving the trunk and axillary regions. The Minor starch-iodine test was negative, confirming the absence of sweating. Histopathological findings demonstrated preserved cutaneous architecture with structurally normal eccrine glands, although ductal degenerative changes and a mild lymphocytic infiltrate were observed.